A: Santander- Schalke 1:1 (0:0), Tchite - Engelaar, Manchester C. - Twente 3:2 (1:1), Wright, Robinho, Benjani - Elia.
| 1. Schalke | 2 | 1 | 1 | | 4:2 | 4 |
| 2. Manchester | 1 | 1 | | | 3:2 | 3 |
| 3. Twente | 2 | 1 | | 1 | 3:3 | 3 |
| 4. Santander | 2 | | 1 | 1 | 1:2 | 1 |
| 5. Paríž SG | 1 | | | 1 | 1:3 | |
B: Met. Charkov - Hertha 0:0. Benfica - Galatasaray 0:2 (0:0), Emre Asik, Umit Karan.
| 1. Galatasaray | 2 | 2 | | | 3:0 | 6 |
| 2. Hertha | 2 | | 2 | | 1:1 | 2 |
| 3. Charkov | 1 | | 1 | | 0:0 | 1 |
| 4. Benfica | 2 | | 1 | 1 | 1:3 | 1 |
| 5. Pireus | 1 | | | 1 | 0:1 | |
C: Stuttgart - P. Belehrad 2:0 (0:0), M. Gómez 2,
Liége - Sevilla 1:0 (1:0), Mbokani.
| 1. FC Sevilla | 2 | 1 | | 1 | 2:1 | 3 |
| 2. Janov | 1 | 1 | | | 2:1 | 3 |
| 3. Liége | 1 | 1 | | | 1:0 | 3 |
| 4. Stuttgart | 2 | 1 | | 1 | 2:2 | 3 |
| 5. Belehrad | 2 | | | 2 | 1:4 | |
D: Spartak Moskva - Udinese 1:2 (1:1), C. Rodríguez - Quagliarella 2 (druhý z 11 m),
Tottenham - D. Záhreb 4:0 (2:0), Bent 3, Huddlestone.
| 1. Udinese | 2 | 2 | | | 4:1 | 6 |
| 2. Tottenham | 2 | 1 | | 1 | 4:2 | 3 |
| 3. Záhreb | 2 | 1 | | 1 | 3:6 | 3 |
| 4. Nijmegen | 1 | | | 1 | 2:3 | |
| 5. Moskva | 1 | | | 1 | 1:2 | |
E: Wolfsburg - Heerenveen 5:1 (2:1), Džeko 2, Grafite, Misimovič, Krzynówek - Väyrynen.
AC Miláno - Braga 1:0 (0:0), 90.+ Ronaldinho.
| 1. AC Miláno | 2 | 2 | | | 4:1 | 6 |
| 2. Wolfsburg | 1 | 1 | | | 5:1 | 3 |
| 3. Braga | 2 | 1 | | 1 | 3:1 | 3 |
| 4. Portsmouth | 1 | | | 1 | 0:3 | |
| 5. Heerenveen | 2 | | | 2 | 2:8 | |
F: Ajax - Žilina 1:0 (1:0), 41
. Luis Suárez.
Ajax: Vermeer - Van der Wiel, Oleguer, Vermaelen, Vertonghen - Gabri, S. De Jong (46. Kennedy), Lindgren (74. Schilder) - Luis Suárez, Huntelaar, Emanuelson.
Žilina: D. Perniš - Pekarík, Šourek, Vomáčka, Tesák - Zd. Štrba, Pečalka (73. M. Ďurica) - Vladavič, Adauto, Jež (88. Piaček) - Štyvar (73. Rilke). 21 321 divákov, rozhodca McDonald (Škót.), ž.k. Pečalka.
Slavia - Aston Villa 0:1 (0:1), Carew.
| 1. Aston Villa | 2 | 2 | | | 3:1 | 6 |
| 2. Hamburg | 1 | 1 | | | 2:1 | 3 |
| 3. Ajax | 2 | 1 | | 1 | 2:2 | 3 |
| 4. Slavia | 1 | | | 1 | 0:1 | |
| 5. Žilina | 2 | | | 2 | 1:3 | |
G: St. Etienne - Trondheim 3:0 (0:0), Ilan, P. Machado, Mirallas,
Valencia - FC Kodaň 1:1 (0:0), Morientes - Santin.
| 1. St. Etienne | 2 | 2 | | | 6:1 | 6 |
| 2. Valencia | 1 | | 1 | | 1:1 | 1 |
| 3. Bruggy | 1 | | 1 | | 0:0 | 1 |
| 4. Kodaň | 2 | | 1 | 1 | 2:4 | 1 |
| 5. Trondheim | 2 | | 1 | 1 | 0:3 | 1 |
H: Poznaň - Nancy 2:2 (2:1), Peszko, Stilič - Malonga, Zerka,
Feyenoord - CSKA 1:3 (1:2), 29. Van Bronckhorst - Vágner Lowe 2, vl. (Van Bronckhorst).
| 1. CSKA | 2 | 2 | | | 6:1 | 6 |
| 2. Nancy | 2 | 1 | 1 | | 5:2 | 4 |
| 3. Poznaň | 1 | | 1 | | 2:2 | 1 |
| 4. La Coruňa | 1 | | | 1 | 0:3 | |
| 5. Feyenoord | 2 | | | 2 | 1:6 | |
